The first promotional video for Grey’s Anatomy season 11 has been released and hints at trouble for Meredith and Derek’s marriage.

At the end of Grey’s Anatomy season 10 fans saw Meredith tell Derek she didn’t want to go to D.C. with him. Instead, she wanted to stay in Seattle and continue her work there.

Well, it doesn’t look like the problem is going to go away anytime soon. And the battle between husband and wife will wear down on their marriage.

The promo starts off replaying a bit of the original argument. Meredith firmly tells Derek, “I am staying here.” Then a flash of April telling Jackson, “He’s dying inside” before showing a shot of a solemn looking Derek. And finally Meredith hugging Alex and telling him she doesn’t know if her marriage can survive.

It looks like Meredith will be spreading distance between her and Derek. Meanwhile, as the last of the original interns – she and Alex will get even closer. He’ll be there consoling her as she works through the issues in her marriage. Which may be causing some trouble in his own relationship with Jo.

Grey’s Anatomy season 11 premieres Thursday September 25 at 8 p.m. on ABC. The title of the first episode is, “I Must Have Lost It on the Wind.”

What do you think will happen with Derek and Meredith on ‘Grey’s Anatomy’?