9:49 pm EDT, September 17, 2019

Alyssa Milano, Holly Marie Combs to guest star as sisters on ‘Grey’s Anatomy’

Charmed Ones, Alyssa Milano and Holly Marie Combs are gearing up to play sisters yet again!

According to Entertainment Weekly, both Alyssa Milano and Holly Marie Combs have signed on to guest star on an upcoming episode of Grey’s Anatomy season 16.

Charmed fans will undoubtedly best know Combs and Milano for portraying sisters Phoebe and Piper Halliwell on the hit sci-fi series, which ran on the WB from 1998 to 2006.

When Alyssa Milano and Holly Marie Combs guest star on Grey’s, they’ll fittingly once again be playing sisters, albeit sisters with a tough decision ahead of them.

According to the announcement, they’ll play sisters called to Grey Sloan Memorial Hospital after their fellow sister suffers an accident on a construction site that leaves her brain dead. Together, they’ll have to decide whether to keep their sister alive on life support or not.

We can’t be the only ones gearing up to bust out the tissues after taking in the storyline in store for Milano and Combs’ guest starring stint on Grey’s Anatomy!

Grey’s Anatomy’s upcoming Charmed reunion isn’t the only reunion coming down the pipeline at ABC.

In fact, Milano and Combs’ involvement with the long running medical drama’s 16th season was announced as part of ABC’s planned Cast from the Past Week.

Beginning October 7, the network’s week-long extravaganza will feature reunited cast members as well as reunited creative teams from some of the biggest hits in television and film, coming on to lend their talents to ABC’s current lineup of shows.

Other reunions set to take place as part of Cast from the Past Week include a Girlfriends reunion on Black-Isn, a Crazy Rich Asians reunion on Fresh Off the Boat, and Blues Brothers 2000 reunion on The Conners and much more!

Alyssa Milano and Holly Marie Combs’ Grey’s Anatomy episode is set to air via ABC on October 7.

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